The accident happened just after noon, on the N11 road at Scarawalsh near Enniscorthy in Wexford.
It is understood she was the front seat passenger in one of the vehicles involved in the collision.
Three other people sustained injuries, and one person remains in a critical condition.
Gardai are appealing for witnesses to contact Enniscorthy Garda Station on 053-9242580, the Garda Confidential Line on 1800 666 111, or any garda station.
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