The hotel is run by young businessman Jim Mansfield Jr.
One of the men was armed and the pair made off with a large sum of money from the Finnstown House Hotel, Lucan, West Dublin.
A 27 year old worker was tied up when the raiders entered the hotel at about 4.10am last night.
Fortunately no one was seriously injured.
A silver Audi A5 car was used for their getaway. the second armed raid on a hotel in 18 months.
Gardai are appealing for information and ask the public to be vigilant of any suspicious activity in their area, hotels they are staying in and are searching for the getaway car.