Elizabeth Clarke, aged 25, young mother of two was last seen in Navan, Co Meath in November 2013.
Despite over two years of relentless searching there has been no information on where she is.
Lena Clarke, the young woman’s grandmother stated her fears that her granddaughter has been murdered.
Ms Clarke’s aunt Geraldine Olliffe said that Elizabeth “completely disappeared” and also said of her two children “They are only two and five now. She wouldn’t miss them growing up”
The family home is situated close to Tower Beach, Portrane in North Co Dublin.
Ms Clarke’s 77 year old grandmother fondly remembers her granddaughter “She was always smiling and was so bubbly. Everybody loved her, that made me so proud”
No one from the Clarke family has seen Elizabeth Clarke since late 2012.
Anthony Clarke, the young woman’s uncle also pleaded for any information saying ” It doesn’t matter how insignificant you think it is, please come forward. There are so many young women in Ireland who have been missing for long, Annie McCarrick, JoJo Dollard, Ciara Breen, we don’t want Elizabeth to be added to that list”
On her last sighting Elizabeth was wearing a yellow hooded top and blue jeans.
She is 5ft 3ins and seven stone in weight.
Anyone with information is asked to please contact Navan Garda Station on 046 9036100 , the the Garda Confidential Telephone Line on 1800 666 111 or any garda station.
The family of Elizabeth Clarke have made an appeal through video, which can be watched at www.independent.ie.